CDC recommends re-prescribed coronavirus booster shots for fall


The Centers for Disease Control and Prevention said Thursday that millions of eligible Americans, including 12-year-olds, will be protected against serious illness and death during a potential rise in covid-19 cases in the fall or winter. recommended getting the updated Omicron-targeting booster shot to enhance the . .

CDC Director Rochelle Wallenski endorsed the advisory committee’s recommendations, paving the way for some clinicians, pharmacies, and other providers to start immunizations this weekend. The Advisory Board voted 13 to 1 to recommend the latest immunizations from Moderna for those 18 and older and Pfizer BioNtech for those 12 and older.

Thursday’s action, along with the Food and Drug Administration’s approval of a day-old shot, marks another turning point in the pandemic and reflects the ongoing struggle to curb disease and death two and a half years into the pandemic’s onset. doing.

“Our latest COVID-19 booster is formulated to better protect against the recently circulating COVID-19 variant,” Walensky said in a statement. “They are designed to help restore defenses that have weakened since previous vaccinations and to provide broader protection against new subspecies. There’s never a bad time to get a -19 booster, and I highly recommend getting it.”

Several advisory panel members expressed concern about the lack of clinical data on the reformulated boosters, but also noted the potential harm of waiting for clinical data until November.

Matthew Daley, a physician at Kaiser Permanente Colorado, said waiting until late November for the deployment of the updated booster shots would result in an additional 9,700 deaths and 137,000 hospitalizations, based on projections presented at the all-day meeting. I said it could happen.

“I think that’s certainly the tension I’m feeling,” said Daly. And I think it will be an effective tool for disease prevention this fall and the end of winter.”

Booster’s latest recommendation comes after the Biden administration and public health experts have warned a public sick of a pandemic of the importance of vaccinating against a virus that is still killing more than 500 people a day on average. We will provide new opportunities to send out the message of America.

Dosages began shipping to pharmacies, clinics and clinics Wednesday after the FDA approved the latest shots from Moderna and Pfizer and their German partner BioNTech. , the updated booster is free.

The new booster is the first change since the mRNA vaccine was rolled out in December 2020 and targets the BA.4 and BA.5 Omicron subvariants prevalent in the US. Officials say the new injections are closer to the prevalent strains and therefore help boost immunity.

So far, vaccines have targeted the original version of the coronavirus, but various variants have emerged. Half of the new booster, known as the bivalent vaccine, contains the original formulation, while the other half contains the most contagious version of the virus since coronavirus swept the world in 2020. Contains recipes for BA.4 and BA.5, which are currently responsible for nearly 90% of U.S. cases, according to the CDC.

The updated booster is for those who received the primary vaccine using the original vaccine or who are eligible to receive the booster at least 2 months after the last vaccine. Even if an individual received a booster of the original formulation, he can get the latest booster if two months have passed since his last injection. Intervals of at least two months are intended to extend immunity, as doing it too early reduces the effectiveness of the vaccine.

Longer intervals between vaccinations reduce the risk of rare side effects such as myocarditis (inflammation of the heart muscle), especially in young adults and teenagers, health officials say.

The CDC estimates that about 200 million Americans age 12 and older are eligible for the latest immunizations. About 22 million adults over the age of 50 have received his second booster shot, but most people over the age of five say it has been at least six months since their last coronavirus vaccine. , CDC’s Sarah Oliver told the advisory board on Thursday.

Americans are slow to get boosters, and experts aren’t sure if reconciled booster intake is different. [coronavirus] vaccination,” said Jen Cates, senior vice president of the Kaiser Family Foundation.

In an email, Cates said, “We don’t know how the swell will occur or rush to boost. About 20% of people who get vaccinated say, ‘The latest vaccine that targets mutations. We are waiting,” Cates said, referring to a recent Kaiser Family Foundation investigation. “On the other hand, it’s hard to see how this could change if people don’t perceive these as better or necessary, or if there are other reasons they don’t want to get boosters.”

Albert Ko, an infectious disease physician and epidemiologist at the Yale School of Public Health, said he was worried about what Americans would face this winter, with more than 500 cases of covid-19 a day in the country. I mentioned that there have been deaths due to

“The low penetration of new boosters is a real and urgent concern, especially at a time when social distancing and face mask use are fading, as we rely on vaccination to protect our communities.”

Panel members reiterated questions among some experts and expressed concern about the lack of human data on shot efficacy, which the FDA relies heavily on mouse studies. Data used by the FDA to approve SCHOTT include data from previous experimental trials, including one that generated virus-fighting antibodies to BA.1, the first subvariant of SCHOTT since December 2020. A human study of bivalent shots was included.

Pablo J. Sanchez, a professor of pediatrics at Ohio State University, said he voted against it because he “really feels we need human data” on the new vaccine.

But Seattle and King County Health Officer Jeffrey Duchin said he was pleased with the animal data supporting the recalibrated boosters. We also mentioned that animal testing is routinely used to adjust for

CDC’s Oliver presented data showing how a September booster vaccination program could avoid significant deaths, hospitalizations, infections, and direct medical costs. Including variants in vaccines broadens antibody responses, he noted.

Previous interest in booster shots has proven lukewarm at best.

Experts said it could reflect people’s lack of correct information about vaccines, partisan differences and practical challenges. Nearly 6 in 10 people who have a boost but are not receiving a boost say they feel well protected. The survey found that 3 in 10 people say they are too busy and 15% are worried about losing their jobs. Democrats are more likely to be vaccinated and boosted than Republicans.

A CDC survey conducted in August at the University of Iowa suggests that more people want to be vaccinated. Oliver said 72% of his eligible respondents said he definitely or probably will get the latest booster against omicron.

Only half of booster-eligible Americans (about 108 million) receive the first recommended booster dose, and only about one-third of those over the age of 50 (about 22 million) receive a second booster. received. A CDC study shows that older adults, college graduates, and those on higher incomes are most likely to still be vaccinated and boosted.

who received a two-shot primary series of mRNA or Novavax vaccine, or Johnson & Johnson single-dose vaccines are covered regardless of whether you have had a booster dose.

FDA officials expect pediatric data on the new booster to be available within the next two months, and may approve it for some children under the age of 12 later this year. I have.

What you need to know about covid booster shots updated for fall

Booster changes are already causing confusion. Some people who signed up to receive the original booster formulation will have to change their appointments to get the new version because the original formulation is no longer approved by the FDA to be used as a booster.

“The last thing we have to do is talk to people who have signed up [for the original booster] Michael Fraser, Chief Executive Officer of the Association of State and Territory Health Officials, said: “While we are seeing lagging demand across the country, this does not build trust among the public and health care providers who are asking health officials what to do now.”

The CDC recommends a coronavirus vaccination for everyone 6 months and older and a booster for everyone 5 years and older who qualifies.

CDC data at Thursday’s meeting showed adults who received the primary series and two boosters had a 14-fold lower risk of death from covid-19 than those who had not been vaccinated. Those who received the booster had a three times lower risk of death than those who received only one booster.

The original vaccine provides strong protection against serious illness and death in generally healthy people, especially if they received the first booster dose, so experts and authorities are questioning whether an updated booster is needed. Opinions are divided. Some experts say it’s not clear how much additional benefit the recalibrated boosters provide.

Only about 1.5 million doses are likely to be available initially, according to information provided to state health officials, so people should check with their local pharmacies and providers to get vaccinated before coming in. You’ll have to visit Another 10 million doses are expected to be delivered next week.

Laurie McGinley contributed to this report.

Leave a Comment